Injectable skin rejuvenation treatments have evolved significantly in recent years. Two of the most talked-about treatments are polynucleotides and Profhilo, both designed to improve skin quality, hydration and overall skin health.
Although these treatments are sometimes compared, they work in different ways and are often recommended for completely different skin concerns.
At Dr Haus Dermatology, our dermatologists and registered nurses will carefully assess your skin before recommending the most appropriate treatment to achieve natural and long-lasting results.
In this guide, we explain the differences between polynucleotides and Profhilo and which may be best for your skin goals.
Polynucleotides are regenerative injectable treatments known as biostimulators derived from highly purified fragments of salmon DNA. These molecules help stimulate the skin’s natural repair processes and improve cellular function.
Polynucleotides work by encouraging:
Rather than simply adding volume, polynucleotides focus on regenerating skin at a cellular level.
They are particularly useful for delicate areas such as:
Polynucleotides are increasingly being used in dermatology because they promote long-term skin regeneration rather than temporary filling.
Profhilo is an injectable treatment made from one of the highest concentrations of hyaluronic acid available.
Unlike dermal fillers, Profhilo does not create volume or contour. Instead, it spreads beneath the skin to deeply hydrate and stimulate collagen production.
Profhilo works by:
The treatment is delivered using a specific injection technique known as the BAP (Bio Aesthetic Points) method, which allows the product to diffuse evenly throughout the skin.
Profhilo is commonly used to treat:
Although both treatments improve skin quality, they work through different biological mechanisms.
Polynucleotides
Profhilo
Polynucleotides are best for:
Profhilo is best for:
Both treatments can be used on the face, but polynucleotides are often preferred for delicate areas such as the under-eye region.
Profhilo, on the other hand, is frequently used on larger treatment areas like the face and neck.
Polynucleotides
Profhilo
Yes. Many dermatologists combine treatments to achieve the best results.
For example:
This combined approach can enhance overall skin quality while addressing different concerns simultaneously.
At Dr Haus Dermatology, we prepare personalised treatment plans to ensure the most effective and natural results for every patient.
Located on Harley Street in London, Dr Haus Dermatology offers advanced dermatological and aesthetic treatments tailored to individual skin concerns.
The clinic specialises in treatments designed to improve skin quality, texture and long-term skin health.
Patients benefit from:
A consultation allows dermatologists or one of our registered nurses to determine whether polynucleotides, Profhilo, or a combination of the two will best suit your skin.
Dr Haus Dermatology is a private dermatology clinic established over 15 years ago on Harley Street, London, providing expert care for both medical and aesthetic skin concerns. The clinic takes a consultation-led approach, with a focus on careful diagnosis, personalised treatment planning, and long-term skin health.
All patients are assessed and treated by experienced Dermatologists, ensuring care is medically led from the outset. The team manages a wide range of skin concerns, from common and complex dermatological conditions to skin cancer checks and aesthetic treatments, always prioritising safety and evidence-based care.
Patients can find out more about the Dermatologists and Nurses behind their care on the Meet the Team page, or make an enquiry via the Contact Us page, or alternatively, chat to us now via WhatsApp. Dr Haus Dermatology welcomes patients from London and across the UK.
Polynucleotides focus on skin regeneration and cellular repair, while Profhilo is very good for patients with dry skin, wrinkles or laxity. Profhilo improves skin hydration and elasticity using hyaluronic acid.
Both treatments can give long lasting results, typically from 6 months and sometimes up to one year. Results and response to treatment will always vary from person to person and will be dependent on factors such as the person’s age and skin condition prior to treatment.
Both treatments are widely used in dermatology and aesthetic medicine and considered very safe when performed by experienced medical professionals. At Dr Haus Dermatology we have been using Profhilo since it was first introduced into the UK in 2016.
Polynucleotides are often preferred for the delicate under-eye area, as they help improve skin quality without adding volume.
Most patients require:
Maintenance treatments may be recommended depending on your skin goals.
If you are considering polynucleotides or Profhilo, the most effective way to determine the right treatment is through a personalised consultation with an experienced dermatology professional.
At Dr Haus Dermatology, every treatment plan is guided by medical expertise, ensuring results that are natural, safe, and tailored to your individual skin needs.
“The prestigious Harley Street clinic is lauded as one of the best London destinations for both medical and cosmetic dermatology, and for those looking for a laser specialist it’s the place.”
— Harper’s Bazaar
Whether your goal is to improve hydration, address early signs of ageing, or regenerate damaged skin, our team will guide you towards the most appropriate treatment.
Book your consultation today and take the first step towards healthier, more radiant skin.
